GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs875971 | 1 | rs55962648 | chr7:65625751 | LOC729156 | chr7:66274980-66309813:- | -0.16 | -3.47 | 0.000572 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs55962648 | chr7:65625751 | RABGEF1 | chr7:66093890-66276446:+ | -0.66 | -14.15 | 3.08E-38 | Aortic root size |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | ANKRD13B | chr17:27916801-27941778:+ | 0.36 | 8.9 | 1.2E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | CORO6 | chr17:27941774-27948441:- | 0.51 | 11.83 | 1.64E-28 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.17 | 6.8E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | GIT1 | chr17:27900487-27916610:- | 0.29 | 6.78 | 3.53E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | LRRC37B2 | chr17:28903483-28992715:+ | 0.17 | 3.78 | 0.000176 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | SSH2 | chr17:27952965-28257018:- | 0.37 | 8.34 | 7.97E-16 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | TP53I13 | chr17:27895739-27900174:+ | 0.21 | 5.6 | 3.54E-8 | Coffee consumption (cups per day) |
| THCA | cis | rs7116495 | 1 | rs55972015 | chr11:71642576 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.96 | 8.7E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs4889609 | 1 | rs55979739 | chr16:31049155 | C16orf93 | chr16:30768753-30773542:- | -0.15 | -4.1 | 4.86E-5 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs55979739 | chr16:31049155 | HSD3B7 | chr16:30996519-31000473:+ | 0.43 | 11.09 | 1.41E-25 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs55979739 | chr16:31049155 | MYST1 | chr16:31128985-31142713:+ | 0.15 | 4.8 | 2.15E-6 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs55979739 | chr16:31049155 | PRSS53 | chr16:31094747-31106276:- | -0.15 | -4.02 | 6.7E-5 | Response to metformin (IC50) |
| THCA | cis | rs1801516 | 1 | rs55985317 | chr11:108110663 | ACAT1 | chr11:107992258-108018889:+ | -0.33 | -7.26 | 1.59E-12 | Melanoma |